What is opioid tolerance?

Opioid tolerance refers to a condition in which a person's response to a drug diminishes over time, necessitating larger doses to achieve the same therapeutic effect initially experienced. This phenomenon occurs as the body adapts to the presence of the opioid, resulting in decreased efficacy at standard doses. In practical terms, individuals who develop tolerance may find that their usual dosage no longer alleviates their pain or produces the desired effects, prompting healthcare providers to increase the dosage. Understanding opioid tolerance is essential for managing pain effectively and mitigating the risk of overdose in patients who require long-term opioid therapy.