What therapy has FDA regulatory approval for the management of opioid use disorder?

Methadone is a well-established medication that has received FDA regulatory approval specifically for the management of opioid use disorder. It is a long-acting opioid agonist that helps to stabilize patients by alleviating withdrawal symptoms and cravings without providing the euphoric effects associated with other opioids. This makes it an effective part of a comprehensive treatment plan for individuals struggling with opioid addiction.

The FDA's approval of methadone is based on its efficacy in helping individuals maintain their recovery, as it allows for a more controlled and gradual approach to detoxification and long-term management. Methadone is typically dispensed through specialized clinics, where patients receive supervised doses as part of their treatment regimen.

In contrast, other options like Mitragyna speciosa (also known as kratom) do not have FDA approval for this purpose and may carry legal and safety concerns. Tizanidine is primarily used as a muscle relaxant and does not address opioid use disorder. Tramadol, while it is an opioid, is not approved for the treatment of opioid use disorder and is associated with its own risks and potential for misuse. Thus, methadone stands out as the only FDA-approved therapy listed, making it a cornerstone in the treatment of opioid use disorder.